Welcome to the International Association for Paratuberculosis (IAP)
Advancing Science and Innovation to Combat Paratuberculosis Worldwide
About the IAP
The International Association for Paratuberculosis (IAP) is a nonprofit scientific organization dedicated to promoting scientific progress on Mycobacterium avium subspecies paratuberculosis (MAP), related mycobacteria, and associated diseases.
Paratuberculosis: The Hidden Challenge Beneath the Surface
Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease, also referred to as paratuberculosis, a chronic infectious disease. Cattle, sheep, and goats are the main ruminants affected, and it causes severe intestinal inflammation, weight loss, and decreased productivity.
Globally, paratuberculosis causes large economic losses, despite the fact that clinical symptoms frequently take years to manifest after the initial infection. Reduced milk production, early culling of infected animals, and higher veterinary costs are the causes of these losses. Effective control of MAP necessitates a multifaceted approach that extends beyond animal management due to its long environmental survival.
Diseases Associated with MAP
Johne’s Disease in Livestock
MAP infection leads to a chronic enteritis characterized by persistent diarrhea, malabsorption, and progressive weight loss. Because the disease has a long incubation period and often subclinical early stages, timely diagnosis and control remain a challenge. The silent spread within herds can devastate livestock operations over time.
Human Health Implications
Global interest in investigating MAP's role in human autoimmune disorders has been sparked by the discovery of MAP in the tissues of some Crohn's disease patients, despite the lack of conclusive evidence. The necessity of interdisciplinary research and a One Health approach is highlighted by this intersection between veterinary and human medicine.
Innovations & Technologies Transforming Paratuberculosis Research
Molecular Diagnostics & Rapid Detection
From cutting-edge PCR tests to genome sequencing, researchers now have super-powered tools to detect and track MAP faster than ever before.
Genomics & Proteomics
Whole-genome sequencing identifies key pathogenic genes, while proteomics uncovers protein markers for vaccine development.
Bioinformatics & Big Data
Cutting-edge computational tools integrate complex data, enhancing disease modeling and guiding targeted interventions.
